Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge
| Autor: | Steven De Keukeleire, Daniëlle Borrey, Wim Decaluwe, Marijke Reynders |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Case Reports in Infectious Diseases, Vol 2016 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2090-6625 2090-6633 |
| DOI: | 10.1155/2016/6207487 |
| Popis: | Necrotizing enterocolitis (NEC) continues to be a major cause of neonatal morbidity and mortality. We describe the added value of therapeutic drug monitoring by presenting the case of a preterm infant with severe NEC treated with meropenem. Dosing strategy will achieve adequate patient outcome when treating pathogens with elevated MIC. As safe as meropenem is, there are not enough data for 40 mg/kg, every 8 h infused over 4 h; accordingly, strict monitoring of blood levels is mandatory. Based on our findings, a 4 h prolonged infusion of 40 mg/kg meropenem, every 8 h, will achieve an adequate patient outcome. |
| Databáze: | Directory of Open Access Journals |
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