Benzylated Sulfamethoxazole Derivatives with Improved Safety Profile as Potential Anti-Mycobacterium tuberculosis and Antibacterial Agents

Autor:	Judas M. Maepa, Tlabo C. Leboho
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Chemistry QD1-999
Zdroj:	Journal of Chemistry, Vol 2023 (2023)
Druh dokumentu:	article
ISSN:	2090-9071
DOI:	10.1155/2023/4805466
Popis:	This study focussed on the synthesis of sulfamethoxazole derivatives and their biological evaluation. The sulfamethoxazole derivatives were successfully biologically evaluated against Mycobacterium tuberculosis, Staphylococcus aureus, and Chinese Hamster Ovarian (CHO) cells. The biological evaluation revealed compounds with improved antitubercular activity and antibacterial activity against S. aureus as well as safety profile when compared to the starting material, sulfamethoxazole. The most active compounds against Mycobacterium tuberculosis were3q with 92% inhibition followed by 3s (90%), 3k (88%), 3t (85%), and 3o (84%).
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5f109b18783843299462d995077b236c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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