Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors

Autor:	Claudia Llinas del Torrent, Laura Pérez-Benito, Gary Tresadern
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	mGlu mGluR homology model virtual screening molecular dynamics allosteric modulator GPCR ligand-based design structure-based design Organic chemistry QD241-441
Zdroj:	Molecules, Vol 24, Iss 6, p 1098 (2019)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules24061098
Popis:	Metabotropic glutamate (mGlu) receptors are a family of eight GPCRs that are attractive drug discovery targets to modulate glutamate action and response. Here we review the application of computational methods to the study of this family of receptors. X-ray structures of the extracellular and 7-transmembrane domains have played an important role to enable structure-based modeling approaches, whilst we also discuss the successful application of ligand-based methods. We summarize the literature and highlight the areas where modeling and experiment have delivered important understanding for mGlu receptor drug discovery. Finally, we offer suggestions of future areas of opportunity for computational work.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e5f0f6650ee446f9bc7ccfdac1ee7d0a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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