Guidelines for the use and interpretation of Alzheimer’s disease biomarkers in clinical practice in Brazil: recommendations from the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology

Autor: Adalberto Studart Neto, Breno José Alencar Pires Barbosa, Artur Martins Coutinho, Leonardo Cruz de Souza, Lucas Porcello Schilling, Mari Nilva Maia da Silva, Raphael Machado Castilhos, Paulo Henrique Ferreira Bertolucci, Wyllians Vendramini Borelli, Hélio Rodrigues Gomes, Gustavo Bruniera Peres Fernandes, Maira Tonidandel Barbosa, Marcio Luiz Figueredo Balthazar, Norberto Anízio Ferreira Frota, Orestes Vicente Forlenza, Jerusa Smid, Sonia Maria Dozzi Brucki, Paulo Caramelli, Ricardo Nitrini, Eliasz Engelhardt, Elisa de Paula França Resende
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Dementia & Neuropsychologia, Vol 18 (2024)
Druh dokumentu: article
ISSN: 1980-5764
DOI: 10.1590/1980-5764-dn-2024-c001
Popis: ABSTRACT In recent years, the diagnostic accuracy of Alzheimer’s disease has been enhanced by the development of different types of biomarkers that indicate the presence of neuropathological processes. In addition to improving patient selection for clinical trials, biomarkers can assess the effects of new treatments on pathological processes. However, there is concern about the indiscriminate and poorly supported use of biomarkers, especially in asymptomatic individuals or those with subjective cognitive decline. Difficulties interpreting these tests, high costs, and unequal access make this scenario even more challenging in healthcare. This article presents the recommendations from the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology (Departamento Científico de Neurologia Cognitiva e Envelhecimento da Academia Brasileira de Neurologia) regarding the rational use and interpretation of Alzheimer’s disease biomarkers in clinical practice. The clinical diagnosis of cognitive-behavioral syndrome is recommended as the initial step to guide the request for biomarkers.
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