Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Autor: Si Naftaly, Itay Cohen, Anat Shahar, Alexandra Hockla, Evette S. Radisky, Niv Papo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-06403-x
Popis: Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.
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