New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing

Autor: Andreas Hoffmann, Holger Leonards, Nora Tobies, Ludwig Pongratz, Klaus Kreuels, Franziska Kreimendahl, Christian Apel, Martin Wehner, Nadine Nottrodt
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Tissue Engineering, Vol 8 (2017)
Druh dokumentu: article
ISSN: 2041-7314
20417314
DOI: 10.1177/2041731417744485
Popis: Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization.
Databáze: Directory of Open Access Journals
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