| Autor: |
Seong A Kim, Seohyun Kim, Yeonsun Hong, Yoonjeong Choi, Yeji Lee, Minsu Kwon, Seung-Yoon Park, Cherlhyun Jeong, Gi-Hoon Nam, Rafael T. Han, In-San Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2025 |
| Předmět: |
|
| Zdroj: |
Translational Oncology, Vol 51, Iss , Pp 102209- (2025) |
| Druh dokumentu: |
article |
| ISSN: |
1936-5233 |
| DOI: |
10.1016/j.tranon.2024.102209 |
| Popis: |
Immune checkpoint inhibition shows promise for cancer treatment, but only a minority of patients respond. Combination strategies have been explored to overcome this resistance. Combining immunogenic clearance using immunogenic cell death inducers with a rho kinase inhibitor enhances phagocytosis of immunogenically dying cancer cells by antigen-presenting cells, stimulating tumor-specific immune responses by activating CD8+ T cells via dendritic cell-mediated priming. This approach increases the responsiveness of immune checkpoint blockade (ICB)-resistant cancer to ICB. However, the precise mechanisms remain unclear. This study elucidates cellular mechanisms of immunogenic clearance enhancing ICB response. Using single-cell RNA sequencing, we observed an increase in effector memory-like CD8+ T cells within the tumor microenvironment with combined treatment. We propose this cell cluster may originate from proliferating CD8+ T cells elevated by immunogenic clearance. Notably, abundant effector memory-like CD8+ T cells in ICB-responsive patients suggest their antitumor effect. Thus, increasing this cell population through enhanced T cell priming may improve the response of ICB-resistant tumors. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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