The optimal duration of continuous respiratory rate monitoring to predict in-hospital mortality within seven days of admission – A pilot study in a low resource setting

Autor: Franck Katembo Sikakulya, Immaculate Nakitende, Joan Nabiryo, Rezvan Pakdel, Sylivia Namuleme, Alfred Lumala, John Kellett
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Resuscitation Plus, Vol 20, Iss , Pp 100768- (2024)
Druh dokumentu: article
ISSN: 2666-5204
DOI: 10.1016/j.resplu.2024.100768
Popis: Background: Currently there are no established benefits from the continuous monitoring of vital signs, and the optimal time period for respiratory rate measurement is unknown. Setting: Low resource Ugandan hospital, Methods: Prospective observational study. Respiratory rates of acutely ill patients were continuously measured by a piezoelectric device for up to seven hours after admission to hospital. Results: 22 (5.5%) out of 402 patients died within 7 days of hospital admission. The highest c-statistic of discrimination for 7-day mortality (0.737 SE 0.078) was obtained after four hours of continuously measured respiratory rates transformed into a weighted respiratory rate score (wRRS). After seven hours of measurement the c-statistic of the wRRS fell to 0.535 SE 0.078. 20% the patients who died within seven days did not have an elevated National Early Warning Score (NEWS) on admission but were identified by the 4-hour wRRS. None of the 88 patients whose average respiratory rate remained between 12 and 20 bpm throughout four hours of observation died within 7 days of admission. A simple predictive model that included the four-hour wRRS, Shock Index and altered mental status had a c-statistic for 7-day in-hospital mortality of 0.843 SE. 0.057. Conclusion: Four hours of continuously measured respiratory rates was the observation period that best predicted 7-day in-hospital mortality. After four hours the discrimination of a weighted respiratory rate score deteriorated rapidly.
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