| Autor: |
Seon Ah Lim, Jungwon Kim, Seunghyun Jeon, Min Hwa Shin, Joonha Kwon, Tae-Jin Kim, Kyungtaek Im, Youngmin Han, Wooil Kwon, Sun-Whe Kim, Cassian Yee, Seong-Jin Kim, Jin-Young Jang, Kyung-Mi Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 10 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2019.00496 |
| Popis: |
Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although majority of TILs consist of CD8+/CD4+ T cells, the presence of NK cells and their role in the pathogenesis of PDAC remains elusive. We performed comprehensive analyses of TIL, PBMC, and autologous tumor cells from 80 enrolled resectable PDAC patients to comprehend the NK cell defects within PDAC. Extremely low frequencies of NK cells ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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