Optimization of Continuous Bioconversion Process of Glycerol to 1,3-Propanediol
| Autor: | Gongxian Xu, Dan Wang, Caixia Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | International Journal Bioautomation, Vol 22, Iss 3, Pp 199-212 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1314-1902 1314-2321 |
| DOI: | 10.7546/ijba.2018.22.3.199-212 |
| Popis: | This paper addresses the optimization of continuous bioconversion process of glycerol to 1,3-propanediol (1,3-PD) by Klebsiella pneumoniae. The studied bioprocess is a complex nonlinear system that involves the gene regulation for dha regulon, enzyme-catalytic kinetics on the reductive pathway, the active transport of glycerol and (passive) diffusion of 1,3-PD across the cell membrane, and the inhibition of glycerol dehydratase (GDHt) and 1,3-propanediol oxidoreductase (PDOR) by 3-hydroxypropionaldehy (3-HPA). We first propose a nonlinear optimization model that can maximize the production rate of 1,3-PD. Then the optimal solution of this optimization problem is obtained by using an interior point method. In this approach a sequence of barrier problems are solved iteratively. We finally obtain the maximum production rate of 1,3-PD increased more than 22.86 times its initial value. |
| Databáze: | Directory of Open Access Journals |
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