| Autor: |
Chenxu Ge, Jun Tan, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Yan Sun, Jing Luo, Chufeng Zhang, Liancai Zhu, Bochu Wang, Minxuan Xu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-33493-5 |
| Popis: |
Mechanisms underlying the pathogenesis of nonalcoholic steatohepatitis are unclear. Here, the authors show that ROS-mediated DUSP22 degradation participates in the progression of fatty liver, contributing to the development of NASH and associated HCC via regulating FAK and its downstream ERK1/2 and NF-κB signaling cascade. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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