| Autor: |
Vincent Nguyen, Max T Eyre, Robert W Aldridge, Anna Aryee, Parth Patel, Wing Lam Erica Fong, Colette Smith, Sarah Beale, Anne M. Johnson, Nicholas Patni, Helen Pineo, Jonathon Taylor, Isobel Braithwaite, Srinivasa Vittal Katikireddi, Cyril Geismar, Ellen Fragaszy, Madhumita Shrotri, Thomas Byrne, Delan Devakumar, Annalan M.D. Navaratnam, Jana Kovar, Andrew Hayward |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Wellcome Open Research, Vol 6 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2398-502X |
| DOI: |
10.12688/wellcomeopenres.17308.1 |
| Popis: |
Background: Household overcrowding is associated with increased risk of infectious diseases across contexts and countries. Limited data exist linking household overcrowding and risk of COVID-19. We used data collected from the Virus Watch cohort to examine the association between overcrowded households and SARS-CoV-2. Methods: The Virus Watch study is a household community cohort of acute respiratory infections in England and Wales. We calculated overcrowding using the measure of persons per room for each household. We considered two primary outcomes: PCR-confirmed positive SARS-CoV-2 antigen tests and laboratory-confirmed SARS-CoV-2 antibodies. We used mixed-effects logistic regression models that accounted for household structure to estimate the association between household overcrowding and SARS-CoV-2 infection. Results: 26,367 participants were included in our analyses. The proportion of participants with a positive SARS-CoV-2 PCR result was highest in the overcrowded group (9.0%; 99/1,100) and lowest in the under-occupied group (4.2%; 980/23,196). In a mixed-effects logistic regression model, we found strong evidence of an increased odds of a positive PCR SARS-CoV-2 antigen result (odds ratio 2.45; 95% CI:1.43–4.19; p-value=0.001) and increased odds of a positive SARS-CoV-2 antibody result in individuals living in overcrowded houses (3.32; 95% CI:1.54–7.15; p-value |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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