THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS
| Autor: | K. S. Krasilnikova, E. G. Polenok, T. P. Anosova, M. P. Anosov, L. A. Gordeyeva, O. A. Glushkova, O. S. Popova, I. V. Shatalina, M. V. Kostyanko, L. S. Raving, A. N. Glushkov |
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| Jazyk: | ruština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Acta Biomedica Scientifica, Vol 0, Iss 3(2), Pp 96-99 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2541-9420 2587-9596 |
| Popis: | The correlation between immune response to benzo(a)pyrene and progesterone in combination with detoxification enzyme gene polymorphism (CYPIA2*1F and GSTTI) and the occurrence of congenital malformations of the fetus was revealed. It is shown that at high ratio of IgA-antibodies to benzo(a)pyrene and to progesterone in conjunction with the mutant allele of the gene CYPIA2*1F and the deletion genotype of the gene GSTTI chance of the reproductive pathology developing increases to 41 times. |
| Databáze: | Directory of Open Access Journals |
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