| Autor: |
Brenda Conceição Guimarães Santana, Daisymara Priscila de Almeida Marques, Andria dos Santos Freitas, Monaliza Macêdo Ferreira, Danielle de Sousa Lopes, Flávia Fonseca Bagno, Flávio Guimarães da Fonseca, Jordana Grazziela Alves Coelho dos Reis, Tiago Antônio de Oliveira Mendes, Jane Lima dos Santos, Carlos Priminho Pirovani |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Heliyon, Vol 9, Iss 5, Pp e15860- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2023.e15860 |
| Popis: |
SARS-CoV-2 is a newly emerging virus from the Coronaviridae family that has already infected over 700 million people worldwide and killed over 6 million. This virus uses protease molecules to replicate and infect the host, which makes these molecules targets for therapeutic substances to eliminate the virus and treat infected people. Through the protein-protein molecular docking approach, we detected two cystatins from Theobroma cacao, TcCYS3 and TcCYS4, described as papain-like protease inhibitors. These inhibitors decreased SARS-CoV-2 genomic copies without toxicity to Vero cells. There is a need to perform comprehensive studies in relevant animal models and to investigate the action mechanisms of protease inhibitors from Theobroma cacao that control the replication of SARS-CoV-2 in human cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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