Serum interleukin 1β and sP-selectin as biomarkers of inflammation and thrombosis, could they be predictors of disease severity in COVID 19 Egyptian patients? (a cross-sectional study)

Autor: Sara El-Sayed Abd El-Ghani, Reham Mohammad Raafat Hamed, Ragaey Ahmad Eid, Ahmed Yassin Mohammed Ibrahim, Hoda M. Abdel-Hamid, Walaa Abdelrahman, Raghda Ebaid Ibrahim, Manar Mahmoud Abdel-Aziz, Marwa Salah Mohamed
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Thrombosis Journal, Vol 20, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 1477-9560
DOI: 10.1186/s12959-022-00428-5
Popis: Abstract Background Thromboembolism was a chief cause of mortality in 70% of patients with COVID-19. Our objective was to see if serum interleukins 1 beta (IL-1β) and soluble platelets selectin (sP-selectin) could serve as novel markers of thromboembolism in COVID-19 patients. Methods This cross sectional study involved 89 COVID-19 patients who were recruited from 1st of February to 1st of May 2021. Clinical and laboratory data were collected, and chest imaging was performed. The levels of IL-1β and sP-selectin were assessed in all cases through ELISA kits. Comparisons between groups were done using an unpaired t-test in normally distributed quantitative variables. In contrast, a non-parametric Mann-Whitney test was used for non-normally distributed quantitative variables. Results Severe COVID-19 infection was associated with higher serum levels of CRP, Ferritin, LDH, D dimer, IL-1β and sP-selectin (P
Databáze: Directory of Open Access Journals
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