Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo

Autor: Ghaleb Bin Huraib, Fahad Al Harthi, Misbahul Arfin, Abdulrahman Aljamal, Abdulqader Saeed Alrawi, Abdulrahman Al-Asmari
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Biomarker Insights, Vol 15 (2020)
Druh dokumentu: article
ISSN: 1177-2719
11772719
DOI: 10.1177/1177271920903038
Popis: The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with susceptibility to autoimmune diseases. The functional polymorphism in PTPN22 at 1857 is a strong risk factor for vitiligo susceptibility in Europeans; however, controversy exits in other populations. Present study was aimed to determine whether the PTPN22 C1857T polymorphism confers susceptibility to vitiligo in Saudi Arabians. Genomic DNA was extracted and amplified using tetra primer amplification-refractory mutation system polymerase chain reaction (ARMS-PCR) method. The frequencies of allele T and genotype CT of PTPN22 C1858T polymorphism were significantly higher, whereas those of allele C and genotype CC were lower in patients as compared with controls ( P < 0.0001). The genotype TT was absent in both the patients and controls. It is concluded that PTPN22 C1858T polymorphism is strongly associated with vitiligo susceptibility. However, additional studies are warranted using large number of samples from different ethnicities and geographical areas.
Databáze: Directory of Open Access Journals
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