Structural basis for the activation and ligand recognition of the human oxytocin receptor

Autor: Yann Waltenspühl, Janosch Ehrenmann, Santiago Vacca, Cristian Thom, Ohad Medalia, Andreas Plückthun
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31325-0
Popis: Here, Waltenspühl et al. report the cryo-EM structure of active human oxytocin receptor in complex with oxytocin and with a heterotrimeric G protein, providing insights into this hormone system critically involved in the regulation of social behaviour and reproduction.
Databáze: Directory of Open Access Journals