Tight junction channel regulation by interclaudin interference

Autor: Nitesh Shashikanth, Marion M. France, Ruyue Xiao, Xenia Haest, Heather E. Rizzo, Jose Yeste, Johannes Reiner, Jerrold R. Turner
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31587-8
Popis: Tight junctions are formed by claudin proteins that can be classified as pore- or barrier-forming. Here, Shashikanth et al. report a third function, termed interclaudin interference, in which one claudin inhibits pore function of another claudin by disrupting its polymeric complexes.
Databáze: Directory of Open Access Journals