Study of Anti-hyperuricemia, Anti-inflammatory, and Anti-nociceptive Effects of Hylocereus undatus Stem Bark Extract in Animal Models
| Autor: | Tri Wahyuni, Sartika Harka Putri, Anton Bahtiar |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Pharmaceutical Sciences and Research, Vol 10, Iss 3, Pp 180-190 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2407-2354 2477-0612 |
| DOI: | 10.7454/psr.v10i3.1340 |
| Popis: | Dragon fruit, known as Hylocereus undantus (HU), has traditionally been utilized in Banyuwangi, East Java, Indonesia, for addressing gout and rheumatism. Despite its empirical use, there is a lack of reported pharmacological research on this plant. This study aimed to explore the properties of HU extract in treating hyperuricemia, inflammation, and pain. Adenine-potassium oxonate-induced mice were employed to evaluate anti-hyperuricemia activity, measuring uric acid, blood urea nitrogen (BUN), and creatinine serum levels. Carrageenan-induced paw edema in rats was used to assess anti-inflammatory activity, while acetic acid-induced abdominal writhing and hot plate tests were conducted to investigate anti-nociceptive effects. The results revealed that administering HU extracts at 400 mg/kg notably reduced uric acid levels (p |
| Databáze: | Directory of Open Access Journals |
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