| Autor: |
Sarah Z. Gavrizi, M.D., Sushila Arya, M.D., Jennifer D. Peck, Ph.D., Jennifer F. Knudtson, M.D., Michael P. Diamond, M.D., Robert A. Wild, M.D., Ph.D., Karl R. Hansen, M.D., Ph.D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
F&S Reports, Vol 3, Iss 1, Pp 57-62 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3341 |
| DOI: |
10.1016/j.xfre.2022.01.001 |
| Popis: |
Objective: To determine if chronic inflammation, assessed by basal high-sensitivity C-reactive protein (hs-CRP) levels, is associated with pregnancy outcomes in women with unexplained infertility undergoing ovarian stimulation with intrauterine insemination. Design: Prospective cohort analysis of the Reproductive Medicine Network’s Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) randomized controlled trial. Setting: Multicenter university-based randomized controlled trial. Patient(s): A total of 781 couples with unexplained infertility. Intervention(s): Secondary analysis. Main Outcome Measure(s): Adjusted risk ratios of live birth, clinical pregnancy, and pregnancy loss rates by hs-CRP levels. Result(s): Associations between hs-CRP levels and clinical pregnancy rates were not observed after adjustment for baseline body mass index. There were fewer live births among women with higher hs-CRP levels, although confidence intervals crossed 1.0. The risk of pregnancy loss was greater in women with increased hs-CRP levels (1–3 mg/L: risk ratio [RR], 1.67; 95% confidence interval [CI], 1.00–2.79; >3–10 mg/L: RR, 1.84; 95% CI, 1.06–3.20; and >10 mg/L: RR, 2.14; 95% CI, 1.05–4.36 compared to women with hs-CRP |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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