Point‐of‐care sural nerve conduction could predict the presence of cardiovascular autonomic neuropathy in type 1 diabetes mellitus
| Autor: | Lía Nattero‐Chávez, Manuel Luque‐Ramírez, Jhonatan Quiñones‐Silva, Laura Montánez, Elena Fernández‐Durán, Beatriz Dorado‐Avendaño, Héctor F. Escobar‐Morreale |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Diabetes Investigation, Vol 13, Iss 8, Pp 1347-1356 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2040-1124 2040-1116 |
| DOI: | 10.1111/jdi.13803 |
| Popis: | ABSTRACT Aims Assessment for cardiovascular autonomic neuropathy (CAN) in patients with type 1 diabetes mellitus remains time‐consuming in the clinical setting. We aimed to examine the diagnostic performance of a portable point‐of‐care diagnostic tool (POCD) for assessing sural nerve conduction during the screening of CAN. Methods Nerve amplitude (AMPPOCD) and conduction velocity (CVPOCD) were measured in a cross‐sectional study including 198 asymptomatic patients with type 1 diabetes. CAN was diagnosed by the Ewing score and power spectral heart rate [low‐frequency (LF) and high‐frequency (HF) activity]. Diagnostic accuracy was determined by ROC curves. Results CVPOCD and AMPPOCD showed positive correlations with LF and HF, and a negative correlation with age. Overall, AMPPOCD had an 81.7% accuracy in identifying CAN [AUC = 0.817 (95% CI 0.692–0.942)] with an AMPPOCD ≤6 μV showing 90% sensitivity and 73% specificity. In a stepwise binary logistic regression analysis, the model (R2: 0.297; P |
| Databáze: | Directory of Open Access Journals |
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