| Autor: |
Qin Zhang, Baoling Bai, Xinyu Mei, Chunlei Wan, Haiyan Cao, Dan Li, Shan Wang, Min Zhang, Zhigang Wang, Jianxin Wu, Hongyan Wang, Junsheng Huo, Gangqiang Ding, Jianyuan Zhao, Qiu Xie, Li Wang, Zhiyong Qiu, Shiming Zhao, Ting Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-018-05451-7 |
| Popis: |
Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tube closure. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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