| Autor: |
Louise Marais, Jianping Dai, Eric Allaire, Mustapha Zidi |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Artery Research, Vol 12 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1876-4401 |
| DOI: |
10.1016/j.artres.2015.10.268 |
| Popis: |
Setting up new strategies to prevent the growth and fatal rupture of aneurysms remains a challenge. The rat xenograft model of abdominal aortic aneurysm (AAA) has been used to develop gene and cell therapies with the aim of countering the expansion of the diseased arterial wall. It is of primary importance to characterize the mechanical behavior of this model before studying the effects of those therapies. Ring tests were performed on 34 samples extracted at several locations along rat AAAs and 8 samples from native healthy rat aortas (NA). The circumferential ultimate strength and extensibility were measured. Material parameters from an exponential isotropic hyperelastic strain energy density function were identified by a finite-element inverse approach. The changes of mechanical properties along the axial direction of AAA were analyzed through the correlation between parameters and external radius. AAAs display significantly higher radius and thickness than NAs and appear weaker, with circumferential ultimate strength and extensibility significantly lower. Best-fit values for material parameters show significant differences between both groups. We reveal strong correlations between ultimate strength and external radius (r=−0.58, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink