| Autor: |
Pei-Xi Zhang, Hong-Xia Zhang, Dai-Liang Hou, Zhi-Chao Xiao, Cheng-Yun Zhou |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
Brazilian Archives of Biology and Technology |
| Druh dokumentu: |
article |
| ISSN: |
1678-4324 |
| DOI: |
10.1590/1678-4324-2019190055 |
| Popis: |
Abstract This study aimed to investigate the cardioprotection of rosuvastatin pre-conditioning (R-Pre) in a rat model of myocardial ischemia / reperfusion (I/R). Male SD rats were assigned into three groups: sham group, I/R group and R-Pre group. Rats in I/R group and R-Pre group received ischemia for 30 min and reperfusion for 2 h. In R-Pre group, rats received intragastrical administration with rosuvastatin at 5 mg/kg once daily for 1 week. After 2-h reperfusion, the cardiac function was detected by ultrasonography; the blood was collected for biochemical analysis; the heart was collected for the TUNEL staining and immunohistochemistry for Bcl-2 and Bax. Our results showed rosuvastatin pre-conditioning for 1 week could significantly reduce the infarct ratio and improve the cardiac function after myocardial I/R injury, in which attenuation of oxidative stress and cell apoptosis played an important role. Our study provides evidence on the cardioprotection of rosuvastatin pre-conditioning and highlight the use of rosuvastatin before cardiopulmonary bypass. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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