Antioxidant and Anticancer Activities of Sand Sea Cucumber (Holothuria scabra) Extracts using Wet Rendering Extraction Method
| Autor: | Nunik Gustini, Diah Anggraini Wulandari, Fauzy Rachman, Eris Septiana, Siti Irma Rahmawati, Gita Syahputra, Martha Sari, Masteria Yunovilsa Putra |
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| Jazyk: | English<br />Indonesian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Jurnal Kimia Sains dan Aplikasi, Vol 26, Iss 1, Pp 1-9 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1410-8917 2597-9914 |
| DOI: | 10.14710/jksa.26.1.1-9 |
| Popis: | Antioxidant and anticancer activities of sand sea cucumber Holothuria scabra (dried and fresh) extracts were studied. The highest extraction yield of sea cucumber H. scabra (3.9%) was obtained using dried H. scabra at 60oC. The highest antioxidant activity was found in fresh H. scabra extract at 60°C with an IC50 value of 629.89 ± 0.15 µg/mL using the ABTS method, and the highest antioxidant activity by DPPH method was found in dried H. scabra extract at 70°C with an IC50 value of 32017.18 ± 0.82 µg/mL. The best antioxidant activity based on FRAP and TBARS methods was found in fresh H. scabra extracts at 80°C, respectively. The highest total phenol and flavonoid contained in dried H. scabra extract were 317.54 ± 8.91 mg GAE/100 g sample and 247.56 ± 11.70 mg QE/100 g sample. H. scabra extracts inhibited more than 50% of the growth of the MDA-MB-231 cell line at concentrations of 25 and 50 μg/mL except for dried H. scabra extracts at 80°C. Similarly, the extracts showed the highest cytotoxic effect up to 100% at the highest concentration (100 μg/mL) except for dried H. scabra extracts at 70°C and 80°C. |
| Databáze: | Directory of Open Access Journals |
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