Multi-ancestry GWAS analysis identifies two novel loci associated with diabetic eye disease and highlights APOL1 as a high risk locus in patients with diabetic macular edema.

Autor: Amy D Stockwell, Michael C Chang, Anubha Mahajan, William Forrest, Neha Anegondi, Rion K Pendergrass, Suresh Selvaraj, Jens Reeder, Eric Wei, Victor A Iglesias, Natalie M Creps, Laura Macri, Andrea N Neeranjan, Marcel P van der Brug, Suzie J Scales, Mark I McCarthy, Brian L Yaspan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: PLoS Genetics, Vol 19, Iss 8, p e1010609 (2023)
Druh dokumentu: article
ISSN: 1553-7390
1553-7404
DOI: 10.1371/journal.pgen.1010609
Popis: Diabetic retinopathy (DR) is a common complication of diabetes. Approximately 20% of DR patients have diabetic macular edema (DME) characterized by fluid leakage into the retina. There is a genetic component to DR and DME risk, but few replicable loci. Because not all DR cases have DME, we focused on DME to increase power, and conducted a multi-ancestry GWAS to assess DME risk in a total of 1,502 DME patients and 5,603 non-DME controls in discovery and replication datasets. Two loci reached GWAS significance (p
Databáze: Directory of Open Access Journals
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