Prooxidant-antioxidant balance in seminal and blood plasma of men with idiopathic infertility and infertile men in combination with rheumatoid arthritis
| Autor: | Roman Fafula, Оksana Melnyk, Natalia Gromnatska, Dmytro Vorobets, Zoryana Fedorovych, Anna Besedina, Zinoviy Vorobets |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Біологічні студії, Vol 17, Iss 2, Pp 15-26 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1996-4536 2311-0783 |
| DOI: | 10.30970/sbi.1702.719 |
| Popis: | Background. Male infertility is one of the most serious medical and social problems. Idiopathic infertility accounts for about 30 % of cases of infertile men. Rheumatoid arthritis is associated with a decreased fertility potential. The aim of the present work was to determine the lipid peroxidation level and the activity of antioxidant enzymes such as glutathione peroxidase and glutathione reductase in seminal plasma and blood plasma of infertile men with idiopathic infertility and concomitant autoimmune joint pathology (rheumatoid arthritis). Materials and Methods. 45 infertile men aged 22–48 were examined. They were divided into 2 groups: first group – 23 somatically healthy patients with idiopathic infertility; second group – 22 infertile men with rheumatoid arthritis. The control group consisted of 27 males with normal semen profile according to the WHO criteria and confirmed parenthood. The concentration of thiobarbituric acid reactive substance and activity of antioxidant enzymes were measured in the blood and seminal plasma. Results. When analyzing the seminal fluid, we found that the TBARS content was 4-fold greater in infertile men with autoimmune pathology compared to fertile men (p |
| Databáze: | Directory of Open Access Journals |
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