The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis

Autor: Erol Keleş, Şule Özkara, Nevin İlhan, Hilal Güngör, Turgut Karlıdağ, Şinasi Yalçın
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Turkish Archives of Otorhinolaryngology, Vol 53, Iss 4, Pp 139-143 (2015)
Druh dokumentu: article
ISSN: 2667-7474
DOI: 10.5152/tao.2015.1187
Popis: Objective:With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D3, active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon- gamma (IFN-γ), which are important for immune response of patients with allergic rhinitis.Methods:Thirty adult patients diagnosed with allergic rhinitis (study group) and 40 healthy volunteers (control group) are examined in the research. IFN-γ, IL-4, IL-10, and total immunoglobulin E (IgE) levels from serum samples and vitamin D3 levels from plasma were determined in all patients.Results:In IgE, IL-4, IL-10, IFN-γ, and 1α,25-dihydroxyvitamin D3 levels (p
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