Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial

Autor: Dr Ranjeeta Thomas, PhD, Ronelle Burger, PhD, Abigail Harper, MSc, Sarah Kanema, BSc, Lawrence Mwenge, MSc, Nosivuyile Vanqa, MPhil, Nomtha Bell-Mandla, MPH, Prof Peter C Smith, MSc, Sian Floyd, MSc, Peter Bock, MRCPUK, Helen Ayles, PhD, Prof Nulda Beyers, PhD, Deborah Donnell, PhD, Sarah Fidler, PhD, Prof Richard Hayes, DSc, Katharina Hauck, PhD, James Hargreaves, Deborah Watson-Jones, Peter Godfrey-Faussett, Anne Cori, Mike Pickles, Nomtha Mandla, Blia Yang, Anelet James, Redwaan Vermaak, Nozizwe Makola, Graeme Hoddinott, Vikesh Naidoo, Virginia Bond, Musonda Simwinga, Alwyn Mwinga, Barry Kosloff, Mohammed Limbada, Justin Bwalya, Chepela Ngulube, Christophe Fraser, Susan Eshleman, Yaw Agyei, Vanessa Cummings, Denni Catalano, Lynda Emel, Lisa Bunts, Heather Noble, David Burns, Alain Kouda, Niru Sista, Ayana Moore, Rhonda White, Tanette Headen, Eric Miller, Kathy Hinson, Sten Vermund, Mark Barnes, Lyn Horn, Albert Mwango, Megan Baldwin, Shauna Wolf, Erin Hughes
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: The Lancet Global Health, Vol 5, Iss 11, Pp e1133-e1141 (2017)
Druh dokumentu: article
ISSN: 2214-109X
DOI: 10.1016/S2214-109X(17)30367-4
Popis: Background: The life expectancy of HIV-positive individuals receiving antiretroviral therapy (ART) is approaching that of HIV-negative people. However, little is known about how these populations compare in terms of health-related quality of life (HRQoL). We aimed to compare HRQoL between HIV-positive and HIV-negative people in Zambia and South Africa. Methods: As part of the HPTN 071 (PopART) study, data from adults aged 18–44 years were gathered between Nov 28, 2013, and March 31, 2015, in large cross-sectional surveys of random samples of the general population in 21 communities in Zambia and South Africa. HRQoL data were collected with a standardised generic measure of health across five domains. We used β-distributed multivariable models to analyse differences in HRQoL scores between HIV-negative and HIV-positive individuals who were unaware of their status; aware, but not in HIV care; in HIV care, but who had not initiated ART; on ART for less than 5 years; and on ART for 5 years or more. We included controls for sociodemographic variables, herpes simplex virus type-2 status, and recreational drug use. Findings: We obtained data for 19 750 respondents in Zambia and 18 941 respondents in South Africa. Laboratory-confirmed HIV status was available for 19 330 respondents in Zambia and 18 004 respondents in South Africa; 4128 (21%) of these 19 330 respondents in Zambia and 4012 (22%) of 18 004 respondents in South Africa had laboratory-confirmed HIV. We obtained complete HRQoL information for 19 637 respondents in Zambia and 18 429 respondents in South Africa. HRQoL scores did not differ significantly between individuals who had initiated ART more than 5 years previously and HIV-negative individuals, neither in Zambia (change in mean score −0·002, 95% CI −0·01 to 0·001; p=0·219) nor in South Africa (0·000, −0·002 to 0·003; p=0·939). However, scores did differ between HIV-positive individuals who had initiated ART less than 5 years previously and HIV-negative individuals in Zambia (−0·006, 95% CI −0·008 to −0·003; p
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