Specificity of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis

Autor:	Nicole H. Trier, Bettina E. Holm, Paul R. Hansen, Ole Slot, Henning Locht, Gunnar Houen
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	anti-citrullinated protein antibodies citrulline homo-citrulline epitopes peptides rheumatoid arthritis Immunologic diseases. Allergy RC581-607
Zdroj:	Antibodies, Vol 8, Iss 2, p 37 (2019)
Druh dokumentu:	article
ISSN:	2073-4468
DOI:	10.3390/antib8020037
Popis:	Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. The majority of individuals with RA are positive for the disease-specific anti-citrullinated protein antibodies (ACPAs). These antibodies are primarily of cross-reactive nature, hence, the true autoantigen to ACPA remains unidentified. In this study, we analyzed the reactivity of RA sera to several post-translationally modified epitopes, in order to further characterize the specific nature of ACPAs by immunoassays. Substituting citrulline with other amino acids, e.g., D-citrulline, homo-citrulline and methyl-arginine illustrated that ACPAs are utmost specific for citrullinated targets. Collectively, these findings support that ACPAs and citrullinated targets are specific for RA, making citrulline-containing peptide targets the most effective assays for detection of ACPAs.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5e0f01591f6e47e29f75ed9653a4bed2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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