Lymphocytopenia and survival after whole‐brain radiotherapy in patients with small‐cell lung cancer

Autor:	Yu‐Jung Lin, Yu‐Mei Kang, Yuan‐Hung Wu, Yi‐Wei Chen, Yu‐Wen Hu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	brain metastasis small‐cell lung carcinoma treatment‐related lymphopenia whole‐brain radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Thoracic Cancer, Vol 14, Iss 14, Pp 1268-1275 (2023)
Druh dokumentu:	article
ISSN:	1759-7714 1759-7706
DOI:	10.1111/1759-7714.14868
Popis:	Abstract Background To investigate whether whole‐brain radiotherapy (WBRT) decreases lymphocyte counts and evaluate the impact of treatment‐related lymphopenia on survival in patients with brain metastasis. Methods Medical records from 60 small‐cell lung cancer patients treated with WBRT from January 2010 to December 2018 were included in the study. Total lymphocyte count (TLC) was obtained pre and post treatment (within 1 month). We performed linear and logistic regression analyses to identify predictors of lymphopenia. The association between lymphopenia and survival was analyzed using Cox regression analysis. Results Thirty‐nine patients (65%) developed treatment‐related lymphopenia. The median TLC decrease was −374 cells/μL (interquartile range −50 to −722, p
Databáze:	Directory of Open Access Journals
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