Non-Viral Carriers for Nucleic Acids Delivery: Fundamentals and Current Applications

Autor:	Sofia Shtykalova, Dmitriy Deviatkin, Svetlana Freund, Anna Egorova, Anton Kiselev
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	non-viral carriers gene delivery endocytosis polyplexes liposomes peptide-based carriers Science
Zdroj:	Life, Vol 13, Iss 4, p 903 (2023)
Druh dokumentu:	article
ISSN:	2075-1729
DOI:	10.3390/life13040903
Popis:	Over the past decades, non-viral DNA and RNA delivery systems have been intensively studied as an alternative to viral vectors. Despite the most significant advantage over viruses, such as the lack of immunogenicity and cytotoxicity, the widespread use of non-viral carriers in clinical practice is still limited due to the insufficient efficacy associated with the difficulties of overcoming extracellular and intracellular barriers. Overcoming barriers by non-viral carriers is facilitated by their chemical structure, surface charge, as well as developed modifications. Currently, there are many different forms of non-viral carriers for various applications. This review aimed to summarize recent developments based on the essential requirements for non-viral carriers for gene therapy.
Databáze:	Directory of Open Access Journals
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