| Autor: |
WEI Feng, CHENG Weiwei, YIN Yafu |
| Jazyk: |
čínština |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Shiyan dongwu yu bijiao yixue, Vol 42, Iss 5, Pp 432-439 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1674-5817 |
| DOI: |
10.12300/j.issn.1674-5817.2021.182 |
| Popis: |
Alzheimer's disease is a common neurodegenerative disease characterized by progressive memory loss and overall cognitive decline. Two typical pathological features are senile plaques and neurofibrillary tangles detected in the brain, which consist of large amounts of precipitated amyloid peptide and hyperphosphorylated Tau protein, respectively. In addition, there are other pathological features such as neuroinflammatory response and extensive loss of neurons. In the past decades, a lot of research has been done on Alzheimer's disease, but its etiology and pathogenesis are still unclear, and there is no ideal treatment or radical cure. This review introduced the characteristics of various transgenic animal models and their current application in preclinical studies, in order to provide theoretical basis for future experimental studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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