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Jie Jiao,1 Shanfa Yu,2 Guizhen Gu,1 Guoshun Chen,3 Huanling Zhang,3 Yuxin Zheng4 1The Third People’s Hospital of Henan Province (Henan Hospital for Occupational Diseases), Zhengzhou, Henan, People’s Republic of China; 2Henan Medical College, Zhengzhou, Henan, People’s Republic of China; 3Wugang Institute for Occupational Health, Wugang, Henan, People’s Republic of China; 4School of Public Health, Qingdao University, Qingdao, Shandong, People’s Republic of ChinaCorrespondence: Shanfa Yu, Henan Medical College, No. 100, Science Avenue, Zhengzhou, Henan, 451191, People’s Republic of China, Tel\Fax +86-0371-6257-6891, Email yu_shanfa@126.comBackground: The relationship between CDH23 gene variants and NIHL is unclear. This study investigates the association between cadherin 23 (CDH23) gene variants and noise-induced hearing loss (NIHL).Methods: This is a case-control study. Workers who were exposed to noise from a steel factory in North China were recruited and divided into two groups: the case group (both ears’ high-frequency threshold average [BHFTA] ≥ 40dB) and the control group (BHFTA ≤ 25 dB). This study used the generalised multifactor dimensionality reduction method to analyse the association among 18 single-nucleotide polymorphisms (SNPs) in CDH23 and NIHL. Logistic regression was performed to investigate the main effects of SNPs and the interactions between cumulative noise exposure (CNE) and SNPs. Furthermore, CNE was adjusted for age, gender, smoking, drinking, physical exercise and hypertension.Results: This study recruited 1,117 participants. The results showed that for rs11592462, participants who carried the GG genotype showed an association with NIHL greater than that of those who carried the CC genotype. Accordingly, genetic variation in the CDH23 gene could play an essential role in determining individual susceptibility to NIHL.Conclusion: Genetic variations in the CDH23 gene may play an important role in determining individual susceptibility to NIHL. These results provide new insight into the pathogenesis and early prevention of NIHL.Keywords: cadherin 23 gene variants, noise-induced hearing loss risk, Chinese population, single-nucleotide polymorphisms, cumulative noise exposure |
