| Autor: |
Hoger Amin, Stella S. Nolte, Bijayalaxmi Swain, Anne C. von Philipsborn |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 26, Iss 11, Pp 108069- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2023.108069 |
| Popis: |
Summary: Inhibitory neurons are essential for orchestrating and structuring behavior. We use one of the best studied behaviors in Drosophila, male courtship, to analyze how inhibitory, GABAergic neurons shape the different steps of this multifaceted motor sequence. RNAi-mediated knockdown of the GABA-producing enzyme GAD1 and the ionotropic receptor Rdl in sex specific, fruitless expressing neurons in the ventral nerve cord causes uncoordinated and futile copulation attempts, defects in wing extension choice and severe alterations of courtship song. Altered song of GABA depleted males fails to stimulate female receptivity, but rescue of song patterning alone is not sufficient to rescue male mating success. Knockdown of GAD1 and Rdl in male brain circuits abolishes courtship conditioning. We characterize the around 220 neurons coexpressing GAD1 and Fruitless in the Drosophila male nervous system and propose inhibitory circuit motifs underlying key features of courtship behavior based on the observed phenotypes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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