Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

Autor: Birgit Gustafson, Annika Nerstedt, Ulf Smith
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10688-x
Popis: Adipose tissue hypertrophy in obesity is associated with insulin resistance and other metabolic complications. Here, the authors analyze subcutaneous adipose tissue from patients with hypertrophic obesity and insulin resistance and find that adipocyte progenitor cells show features of senescence and have poor differentiation capacity.
Databáze: Directory of Open Access Journals