Effect of sidedness on survival among patients with early-stage colon cancer: a SEER-based propensity score matching analysis

Autor: Zhuang-Sheng Huang, Jun-Wei Wu, Ying Li, Yu-Hai Lin, Xu-Yuan Li
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: World Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-7 (2021)
Druh dokumentu: article
ISSN: 1477-7819
DOI: 10.1186/s12957-021-02240-3
Popis: Abstract Background Most previous studies compared survival between left-sided and right-sided colon cancer without adjustment for clinicopathological parameters. We investigated the effect of sidedness on survival among patients with early-stage colon cancer, using a propensity score matching method. Methods The 18 registry custom data within the SEER database were used to identify patients who were diagnosed with colon cancer between 2010 and 2014. A propensity score matching analysis was performed using the nearest neighbor method. Survival was estimated using the Kaplan–Meier method. A Cox proportional hazards model was applied to determine the prognostic factors. Results In the unmatched cohort, 25,094 (35.72%) patients were diagnosed with left-sided colon cancer and 45,156 (64.28%) with right-sided colon cancer. After propensity score matching, each cohort included 5118 patients, and the clinicopathological characteristics were well balanced. In the unmatched cohort, left-sided colon cancer had superior all-cause (χ 2=315, P
Databáze: Directory of Open Access Journals