| Autor: |
Youn Ri Lee, Sang Hoon Lee, Gwi Yeong Jang, Yoon Jeong Lee, Min Young Kim, Yun-Bae Kim, Junsoo Lee, Heon Sang Jeong |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Food & Nutrition Research, Vol 63, Iss 0, Pp 1-10 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1654-661X |
| DOI: |
10.29219/fnr.v63.3603 |
| Popis: |
Background: To overcome disadvantages of germinated brown rice, we germinated rough rice and tested effects of its useful ingredients on prevention of diabetes. Objective: This study investigated the in vitro antioxidant and in vivo antidiabetic effects of rough rice (Oryza sativa L.) with hulls, before and after germination. Rough rice was germinated for 4 days and extracted with water at 120°C. Design: This study measured antioxidants and antioxidative effects and inhibitory activities against α-amylase and α-glucosidase of rough rice before and after germination and investigated antidiabetic effects of rough rice through animal experiments. Results: All these factors increased after germination. Also, α-amylase and α-glucosidase inhibition and glucose uptake by 3T3-L1 adipocytes were significantly increased after germination. Oral administration of the germinated rough rice extract for 8 weeks significantly increased insulin levels and decreased blood glucose levels in a C57BLKS/J-db/db mice model. Immunohistochemical analysis showed that germinated rough rice effectively protected against liver, kidney, and pancreatic tissue damage. Discussion: Useful ingredients in germinated rough rice could be used to prevent diabetes. Conclusions: These results suggest that germinated rough rice extract had a beneficial effect on diabetes by increasing the antioxidant activity and further purification studies are necessary to elucidate the mechanism of the extract’s antidiabetic activity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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