β‐Cell failure in diabetes: Common susceptibility and mechanisms shared between type 1 and type 2 diabetes

Autor:	Hiroshi Ikegami, Naru Babaya, Shinsuke Noso
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	β‐Cell failure Endoplasmic reticulum stress Oxidative stress Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Journal of Diabetes Investigation, Vol 12, Iss 9, Pp 1526-1539 (2021)
Druh dokumentu:	article
ISSN:	2040-1124 2040-1116
DOI:	10.1111/jdi.13576
Popis:	Abstract Diabetes mellitus is etiologically classified into type 1, type 2 and other types of diabetes. Despite distinct etiologies and pathogenesis of these subtypes, many studies have suggested the presence of shared susceptibilities and underlying mechanisms in β‐cell failure among different types of diabetes. Understanding these susceptibilities and mechanisms can help in the development of therapeutic strategies regardless of the diabetes subtype. In this review, we discuss recent evidence indicating the shared genetic susceptibilities and common molecular mechanisms between type 1, type 2 and other types of diabetes, and highlight the future prospects as well.
Databáze:	Directory of Open Access Journals
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