ANALYSIS OF CHANGES OF SERUM BETA-2-MICROGLOBULIN AND HEMATOLOGICAL PARAMETERS IN PATIENTS WITH HIV-ASSOCIATED NEUROLOGICAL DISEASES
| Autor: | L. R. Shostakovych-Koretskaya, K. Y. Lytvyn, O. O. Volikova, I. O. Gubar, Z. O. Chykarenko, O. A. Kushnerova, O. V. Sheveleva |
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| Jazyk: | ukrajinština |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Vіsnik Naukovih Doslіdžen', Vol 0, Iss 3 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1681-276X 2415-8798 |
| DOI: | 10.11603/2415-8798.2017.3.8092 |
| Popis: | Patients with the fourth clinical stage of HIV infection with neurological involvement present with tendency to increase the level of serum beta-2-microglobulin (MG ) and to show significant differences in the main indicators of the hematological and immunological profile in comparison with the group of patients without involvement of the nervous system. The aim of the study – to determine the level of 2-microglobulin and its relation to the main hematological and immunological parameters in patients of the fourth clinical stage of HIV infection in the presence or absence of diseases of the central nervous system.divided into two groups: the first group consisted of 38 patients with clinical-relevant diseases other than neurological, the second group consisted of 39 patients who had HIV-associated neurological diseases. The control group consisted of 15 healthy donors, of corresponding sex and age distribution. Determination of beta-2-microglobulin was performed by EL ISA with standard test systems (US Ave). The statistical processing of the results was carried out using the licensed software product STAT IST ICA v.6.1®. Results and Discussion. A significant difference has been established for both markers of the immune status and hemogram indices. Among those who had neurological diseases (group 2), leucopenia was determined at 3.88 ± 0.27 g/L versus 5.07 ± 0.27 g/L (p |
| Databáze: | Directory of Open Access Journals |
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