| Autor: |
Domenic A. Sica, MD, Pieter Muntendam, MD, Rene L. Myers, PhD, Jozine M. ter Maaten, MD, PhD, Mark E. Sale, MD, Rudolf A. de Boer, MD, PhD, Bertram Pitt, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
JACC: Basic to Translational Science, Vol 3, Iss 1, Pp 25-34 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2452-302X |
| DOI: |
10.1016/j.jacbts.2017.10.001 |
| Popis: |
Parenteral diuretics form the cornerstone of decongestion in heart failure. However, parenteral therapy routinely requires emergency room or inpatient care. A novel buffered furosemide formulation with neutral pH was developed to offer “hospital-strength” diuresis for outpatient use, including self-administration at home. Subcutaneous infusion using a biphasic delivery profile resulted in complete bioavailability (99.65%) and equivalent diuresis when compared with intravenous administration. Subcutaneous administration of buffered furosemide was well tolerated with no evidence of any drug-induced skin reactions. Subcutaneous infusion of buffered furosemide in the outpatient setting or home may help to reduce the burden of heart failure. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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