D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review

Autor: Loris Wauthier, Julien Favresse, Michaël Hardy, Jonathan Douxfils, Grégoire Le Gal, Pierre-Marie Roy, Nick van Es, Cihan Ay, Hugo ten Cate, Thierry Vander Borght, Michaël V. Dupont, Thomas Lecompte, Giuseppe Lippi, François Mullier
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Diagnostics, Vol 12, Iss 11, p 2770 (2022)
Druh dokumentu: article
ISSN: 2075-4418
DOI: 10.3390/diagnostics12112770
Popis: D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. The intended use of the tests depends largely on the assay used, and local guidance should be applied. D-dimer testing may suffer from diagnostic errors occurring throughout the pre-analytical, analytical, and post-analytical phases of the testing process. This review aims to provide an overview of D-dimer testing and its value in diagnosing PE and discusses the variables that may impact the quality of its laboratory assessment.
Databáze: Directory of Open Access Journals