Analysis of the adiponectin paradox in healthy older people

Autor: Carina O. Walowski, Catrin Herpich, Janna Enderle, Wiebke Braun, Marcus Both, Mario Hasler, Manfred J. Müller, Kristina Norman, Anja Bosy‐Westphal
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 270-278 (2023)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13127
Popis: Abstract Background It remains unknown why adiponectin levels are associated with poor physical functioning, skeletal muscle mass and increased mortality in older populations. Methods In 190 healthy adults (59–86 years, BMI 17–37 kg/m2, 56.8% female), whole body skeletal muscle mass (normalized by height, SMI, kg/m2), muscle and liver fat were determined by magnetic resonance imaging. Bone mineral content (BMC) and density (BMD) were assessed by dual X‐ray absorptiometry (n = 135). Levels of insulin‐like growth factor 1 (IGF‐1), insulin, inflammation markers, leptin and fibroblast growth factor 21 were measured as potential determinants of the relationship between adiponectin and body composition. Results Higher adiponectin levels were associated with a lower SMI (r = −0.23, P
Databáze: Directory of Open Access Journals
Externí odkaz: