An Observational Study of the Relationship Between Outcome and Platelet Reactivity in Chinese Patients Undergoing PCI Loading with 600 mg Clopidogrel

Autor: Jing-xiu Li, Ling Weng, Xue-qi Li, Yang Li, Shu-jun Yan, Zhao-yan Song, Xue-yan Zhang, Li Cha, Lin Lin, Tian-shu Yang, Wei-jun Lv, Ying-nan Dai, Ye-ping Chen, De-Jun Xia, Xin Li, En-ze Jin
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cardiovascular Innovations and Applications, Vol 5, Iss 1, p 27 (2020)
Druh dokumentu: article
ISSN: 2009-8782
2009-8618
DOI: 10.15212/CVIA.2019.0580
Popis: Objectives: We sought to determine whether high posttreatment platelet reactivity (HPPR) to a 600 mg loading dose of clopidogrel affects outcomes in Chinese patients with acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI) and to investigate whether there is a relationship between the number of platelet reactivity units (PRUs) and the characteristics of the patients. Background: Although impaired platelet response to clopidogrel is a strong predictor of unfavorable outcome after PCI, the impact of HPPR to a 600 mg loading dose of clopidogrel in Chinese patients with ACS undergoing PCI is still unknown. Methods: We performed observational research on 134 unselected patients with ACS undergoing urgent or planned PCI with a 600 mg loading dose of clopidogrel. Platelet activation was expressed as the PRU value measured by the VerifyNow assay. Results: Among the 134 patients (mean age 60.62 years [standard deviation 9.13 years], 60.4% male), there were 46 patients with HPPR (34.3%) and 88 patients without HPPR (65.7%). At a mean follow-up of 6 months (standard deviation 1 month), the rates of cardiac death, unstable angina, and rehospitalization for target lesion revascularization were higher in the HPPR group (19.6% vs. 6.8%, P=0.029). Multivariate analysis identified hemoglobin level and sex as independent predictors of the PRU value ( y =456.355−1.736 x 1 −31.880 x 2 , P
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