Tissue-specific regulation of IRS-1 in unilaterally nephrectomized rats
| Autor: | A.D. Sasse, E. Chen, C.R.O. Carvalho, J.A.R. Gontijo, S.L. Brenelli, M.J.A. Saad |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 30, Iss 10, p 1163 (1997) |
| Druh dokumentu: | article |
| ISSN: | 0100-879X 1414-431X |
| DOI: | 10.1590/S0100-879X1997001000004 |
| Popis: | Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate 1 (IRS-1). IRS-1 is also a substrate for different peptides and growth factors, and a transgenic mouse "knockout" for this protein does not have normal growth. However, the role of IRS-1 in kidney hypertrophy and/or hyperplasia was not investigated. In the present study we investigated IRS-1 protein and tyrosine phosphorylation levels in the remnant kidney after unilateral nephrectomy (UNX) in 6-week-old male Wistar rats. After insulin stimulation the levels of insulin receptor and IRS-1 tyrosine phosphorylation were reduced to 79 ± 5% (P |
| Databáze: | Directory of Open Access Journals |
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