| Autor: |
Monique Andrade Baron, Ludmila Rodrigues Pinto Ferreira, Priscila Camillo Teixeira, Ana Iochabel Soares Moretti, Ronaldo Honorato Barros Santos, Amanda Farage Frade, Andréia Kuramoto, Victor Debbas, Luiz Alberto Benvenuti, Fabio Antônio Gaiotto, Fernando Bacal, Pablo Pomerantzeff, Christophe Chevillard, Jorge Kalil, Edecio Cunha-Neto |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2235-2988 |
| DOI: |
10.3389/fcimb.2022.836242 |
| Popis: |
Chronic Chagas disease (CCC) is an inflammatory dilated cardiomyopathy with a worse prognosis compared to other cardiomyopathies. We show the expression and activity of Matrix Metalloproteinases (MMP) and of their inhibitors TIMP (tissue inhibitor of metalloproteinases) in myocardial samples of end stage CCC, idiopathic dilated cardiomyopathy (DCM) patients, and from organ donors. Our results showed significantly increased mRNA expression of several MMPs, several TIMPs and EMMPRIN in CCC and DCM samples. MMP-2 and TIMP-2 protein levels were significantly elevated in both sample groups, while MMP-9 protein level was exclusively increased in CCC. MMPs 2 and 9 activities were also exclusively increased in CCC. Results suggest that the balance between proteins that inhibit the MMP-2 and 9 is shifted toward their activation. Inflammation-induced increases in MMP-2 and 9 activity and expression associated with imbalanced TIMP regulation could be related to a more extensive heart remodeling and poorer prognosis in CCC patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
