| Autor: |
Zhen-Hui Xin, Hui-Hui Yang, Yu-Han Gan, Ya-Li Meng, Ya-Peng Li, Li-Ping Ge, Cun-Hui Zhang, Lian-Na Liu, Yan-Fei Kang |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 143, Iss 3, Pp 238-241 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1016/j.jphs.2020.03.007 |
| Popis: |
Resveratrol has been extensively studied as the anti-cancer agent. A variety of resveratrol analogues have been developed with structural modification to improve its bioactivity. In this work, resveratrol analogues, compound 1-4, were designed and synthesized with the Stille–Heck reaction. These results showed compound 1–4 had better anticancer effect than that of parent resveratrol. Especially compound 1 ((E)-4,4′-(ethene-1,2-diyl)bis(3-methylphenol)) displayed the excellent cytotoxicity and high selectivity. The mechanism research indicated compound 1 inhibited cell proliferation by binary paths of cell cycle arrest in S phase regulated by cyclin A1/A2 and apoptosis induction mediated by Bax/Bcl2 in a prooxidant manner. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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