Safety Profile of Monoclonal Antibodies and Subsequent Drug Developments in the Treatment of Paroxysmal Nocturnal Hemoglobinuria

Autor:	Vasantha Mallenahalli Neeekantappa, Ashwin Kamath, Poovizhi Bharathi Rajaduraivelpandian
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	paroxysmal nocturnal hemoglobinuria eculizumab ravulizumab adverse drug reaction challenges investigational new drugs Medicine (General) R5-920
Zdroj:	Medicina, Vol 60, Iss 3, p 379 (2024)
Druh dokumentu:	article
ISSN:	1648-9144 1010-660X
DOI:	10.3390/medicina60030379
Popis:	Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease characterized by intravascular hemolysis due to the targeting of affected red blood cells by the complement system. Eculizumab and ravulizumab are two monoclonal antibodies that inhibit the complement system’s components and have been shown to significantly improve survival and quality of life. This review describes the role of these monoclonal antibodies in the treatment of PNH with an emphasis on their safety profile. The challenges in the use of these drugs and new drugs in various stages of drug development are also described, which may be helpful in addressing some of these challenges.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5d7ba4606684416a9fc0fa6a19f37307 Zobrazit plný text záznamu View record in DOAJ