Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators
| Autor: | Claudio Blasi, Eunjung Kim, Anne A. Knowlton |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Autoimmune Diseases, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2090-0422 2090-0430 |
| DOI: | 10.1155/2012/346501 |
| Popis: | The diabetes-atherosclerosis relationship remains to be fully defined. Repeated prolonged hyperglycemia, increased ROS production and endothelial dysfunction are important factors. One theory is that increased blood levels of heat shock protein (HSP)60 are proinflammatory, through activation of innate immunity, and contribute to the progression of vascular disease. It was hypothesized that improvement of diabetes control in patients presenting with metabolic syndrome would lower HSP60, and anti-HSP60 antibody levels and decrease inflammatory markers. Paired sera of 17 Italian patients, before and after intensive treatment, were assayed for cytokines, HSP60 and anti-HSP60 antibodies. As expected, intensive treatment was associated with a decrease in HgbA1C (P |
| Databáze: | Directory of Open Access Journals |
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