Three novel polymorphic microsatellite markers for the glaucoma locus GLC1B by datamining tetranucleotide repeats on chromosome 2p12-q12

Autor:	Carlos Murga-Zamalloa, Maria Luisa Guevara-Fujita, Alejandro Estrada-Cuzcano, Ricardo Fujita
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	GLC1B microsatellite polymorphic markers tetranucleotide tandem repeat gene mapping glaucoma Genetics QH426-470
Zdroj:	Genetics and Molecular Biology, Vol 32, Iss 4, Pp 720-722 (2009)
Druh dokumentu:	article
ISSN:	1415-4757 1678-4685
Popis:	In order to identify new markers around the glaucoma locus GLC1B as a tool to refine its critical region at 2p11.2-2q11.2, we searched the critical region sequence obtained from the UCSC database for tetranucleotide (GATA)n and (GTCT)n repeats of at least 10 units in length. Three out of four potential microsatellite loci were found to be polymorphic, heterozygosity ranging from 64.56% to 79.59%. The identified markers are useful not only for GLC1B locus but also for the study of other disease loci at 2p11.2-2q11.2, a region with scarcity of microsatellite markers.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d5d6d129e2cd41eb901dc3b5cf23dd15 Zobrazit plný text záznamu View record in DOAJ